Searchable abstracts of presentations at key conferences in endocrinology

ea0084op-04-20 | Oral Session 4: Basic 1 | ETA2022

Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation

de Assis Leonardo , Harder Lisbeth , Thalles Lacerda Jose , Parsons Rex , Kaehler Meike , Cascorbi Ingolf , Nagel Inga , Rawashdeh Oliver , Mittag Jens , Oster Henrik

Cellular 24-hour rhythms depend on transcriptional programs controlled by a set of circadian clock genes/proteins. Systemic factors like humoral and neuronal signals, oscillations in body temperature, and food intake align physiological circadian rhythms with external time. Thyroid hormones (THs) are major regulators of circadian clock target processes such as energy metabolism, but little is known about how fluctuations in TH levels affect the circadian coordination of tissue...